Sex-specific association of depressive symptom trajectories with cognitive decline and clinical progression in mild cognitive impairment.

ABSTRACT:

Introduction

Sex differences in the association between depressive symptoms and cognitive decline or dementia risk among older adults remain controversial. Reliance on single time point assessments of depressive symptoms, which fail to capture their dynamic course, may contribute to the inconsistencies.

Methods

We investigated the sex-specific associations of longitudinal trajectories of depressive symptoms with cognitive decline and progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia among 811 individuals with MCI.

Results

In men, increasing depressive symptoms were associated with significantly steeper rates of cognitive decline, as measured by global cognitive and functional outcomes, and with an increased risk of dementia compared

SUBMITTER: Wang X 

PROVIDER: S-EPMC12319156 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature