Impact of hippocampal α-synuclein oligomers on cognitive trajectory in patients with dementia with Lewy bodies.

ABSTRACT:

Introduction

Increasing evidence indicates that α-synuclein (αSYN) oligomers are toxic. We sought to determine whether αSYN oligomers were associated with faster cognitive decline in prospectively-followed patients with dementia with Lewy bodies (DLB).

Methods

Eight autopsy-confirmed patients with DLB were selected based on rapid or slow cognitive decline determined by the rate of change of Mini-Mental State Examination (MMSE) scores. Quantitative neuropathologic analysis of αSYN oligomers, Lewy-related pathology, phosphorylated tau, and amyloid-β was conducted in hippocampal subfields (CA1-4 and subiculum) and the entorhinal cortex.

Results

DLB with rapid cognitive decline showed greater CA1 αSYN oligomer burden (p = 0.029) and tau burden (p = 0.029) than DLB with sl

SUBMITTER: Sekiya H 

PROVIDER: S-EPMC12319237 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature