ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment.

ABSTRACT: ARID1A is a frequently mutated gene in gastric cancers (GCs), particularly in those associated with the Epstein-Barr virus (EBV), which also often shows PIK3CA mutations and CDKN2A silencing. However, the role of these alterations in the development of GC remains unclear. Here, using Tff1Cre; Arid1a ^flox/flox; Cdkn2a (p16) ^flox/flox; LSL-Pik3ca ^H1047R mice (APP mice), we found that Arid1a deletion alone promoted a type 2 immune microenvironment marked by the infiltration of type 2 innate lymphoid cells (ILC2s), eosinophils, mast cells, and M2 macrophages via triggering aberrant IL-33-expressing pit lineage differentiation in stem/progenitor cells. Targeting interleukin (IL)-33, IL-13, and ILC2 a

SUBMITTER: Arai J 

PROVIDER: S-EPMC12319253 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature