MRNA folding algorithms for structure and codon optimization.

ABSTRACT: mRNA technology has revolutionized vaccine development, protein replacement therapies, and cancer immunotherapies, offering rapid production and precise control over sequence and efficacy. However, the inherent instability of mRNA poses significant challenges for drug storage and distribution, particularly in resource-limited regions. Co-optimizing RNA structure and codon choice has emerged as a promising strategy to enhance mRNA stability while preserving efficacy. Given the vast sequence and structure design space, specialized algorithms are essential to achieve these qualities. Recently, several effective algorithms have been developed to tackle this challenge that all use similar underlying principles. We call these specialized methods mRNA folding algorithms as they generalize classic

SUBMITTER: Ward M 

PROVIDER: S-EPMC12319323 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature