Role of homovanillic acid esters in the regulation of skin inflammatory pathways and their effect on tight junction protein expression.

ABSTRACT:

Introduction

In the context of epidermal inflammation, the inflammatory response not only involves the release of inflammatory cytokines like interleukin 8 (IL-8), but also modulation of tight junction protein expression levels. Previous studies showed that the tight junction protein claudin 1 (CLDN1) is upregulated during tumor necrosis factor α (TNFα)-induced inflammation by capsaicin in keratinocytes in a transient receptor potential channel vanilloid 1 (TRPV1)-dependent manner. However, the caveat with TRPV1 ligands is the undesired pain response elicited by the activation of neuronal TRPV1 channels. In this study, we hypothesized that also less or non-pungent homovanillic acid esters as structural analogs of capsaicin target CLDN1 upregulation during inflammation.

Methods</

SUBMITTER: Cervantes Recalde MF 

PROVIDER: S-EPMC12319341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature