Association between estimated glucose disposal rate and cardiovascular disease prevalence and mortality outcomes in metabolic dysfunction-associated steatotic liver disease: a comparative analysis of insulin resistance markers.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD), primarily driven by insulin resistance (IR), is emerging as a significant public health concern. While the estimated glucose disposal rate (eGDR), a novel marker of IR, could be useful in predicting adverse outcomes in diabetes, its role in MASLD remains unclear.

Methods

We used data from the National Health and Nutrition Examination Survey (NHANES) collected from 1999 to 2018, and combined cross-sectional and cohort study designs to explore the associations between eGDR, cardiovascular disease (CVD) outcomes in US adults with MASLD. Here, MASLD was defined using the fatty liver index or hepatic steatosis index along with cardiometabolic risk factors. We applied survey-weighted logistic regression t

SUBMITTER: Chen X 

PROVIDER: S-EPMC12319350 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature