Role of obesity and estrogen deficiency in non‑alcoholic fatty liver disease: Insights from a mouse model.

ABSTRACT: The prevalence of non‑alcoholic fatty liver disease (NAFLD) increases in post‑menopausal women, driven by obesity and metabolic syndrome (MS). However, the pathogenesis of this interaction remains poorly understood. The present study investigated the interplay between obesity, menopause and NAFLD in a C57BL6/J mouse model of diet‑induced obesity. The study included male and female animals, in which a subgroup of females underwent ovariectomy to simulate menopause. Mice were fed a high‑fat diet for 6 months which resulted in them becoming overweight, and developing hyperglycemia and insulin resistance. The present study analyzed liver histology, inflammatory markers and hepatic lipid profiles. All obese animals showed liver steatosis, hepatocyte ballooning and fibrosis. Sex‑related differen

SUBMITTER: Afonso-Ali A 

PROVIDER: S-EPMC12319388 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature