Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using Caenorhabditis elegans.

ABSTRACT: Few of the many chemicals that regulatory agencies are charged with assessing for risk have been carefully tested for developmental neurotoxicity (DNT). To speed up assessment, and to reduce the use of vertebrate animals, great effort is being devoted to alternative laboratory models for DNT. A major DNT mechanism is altered neuronal architecture resulting from chemical exposure during neurodevelopment. Caenorhabditis elegans is a nematode that has been extensively studied by neurobiologists and developmental biologists, and to a lesser extent by neurotoxicologists. The development of the nervous system in C. elegans is easily visualized, entirely invariant, and fully mapped. We hypothesized that C. elegans could be a powerful in vivo model to test chemicals for their potential to alter ne

SUBMITTER: Huayta J 

PROVIDER: S-EPMC12319415 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature