Diagnostic Test Accuracy of Cytosponge-Trefoil Factor 3 for Barrett Esophagus: A Systemic Review and Meta Analysis.

ABSTRACT:

Introduction

Barrett's esophagus (BE), characterized by the replacement of normal esophageal squamous epithelium with columnar metaplasia, poses a risk of progression to esophageal adenocarcinoma. Early detection is essential to prevent malignant transformation. The Cytosponge, a novel, minimally invasive cell collection device, has been proposed as a diagnostic tool for BE by identifying trefoil factor 3 (TFF3)-positive cells. This meta-analysis evaluates the diagnostic accuracy of the Cytosponge technique for detecting BE.

Methods

A systematic literature search was performed using PubMed and Web of Science for studies published up to May 2024. Two reviewers independently screened studies, extracted data, and assessed the risk of bias using the QUADAS-2 tool. A bivariate ra

SUBMITTER: Kakar MT 

PROVIDER: S-EPMC12319419 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature