The Effect of Hyperoxia on Nitric Oxide Metabolism in the Skeletal Muscle of Male Type 2 Diabetic Rats.

ABSTRACT:

Introduction

Hypoxia is involved in the pathophysiology of type 2 diabetes (T2D), and oxygen therapy (hyperoxia) has been proposed for managing T2D. As a side effect, hyperoxia increases nitric oxide (NO) metabolism and decreases NO bioavailability. This study aims to investigate the effect of hyperoxia on NO synthases (NOSs), which produce NO from L-arginine and arginase, which degrades L-arginine in the soleus muscle (SM) of rats with T2D.

Methods

A combined high-fat diet and a low dose of streptozotocin (30 mg/kg) were used to induce T2D in rats. Rats with T2D were divided into four groups (n = 6/group): Control rats exposed to normoxia (Control), control rats exposed to hyperoxia (C + HOX), diabetic rats exposed to normoxia (T2D) and diabetic rats exposed to hyperoxia (T

SUBMITTER: Mousavi M 

PROVIDER: S-EPMC12319423 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature