Self-assembly of short biopeptides onto skin tissue components studied using QCM-D.

ABSTRACT:

Objective

To enable the discovery of more effective formulations for cosmetic and dermatological applications by understanding the interactions of widely used bioactive ingredients with skin biomolecular components.

Methods

Affinities of six common oligopeptide utilized in biomedical application to five primary skin biomolecules (collagen, elastin, laminin, fibronectin and hyaluronic acid) were measured by monitoring their adsorption and subsequent self-assembly using quartz crystal microbalance with dissipation (QCM-D).

Results

Chemical compositions of both the adsorbates (oligo peptides) and the substrates (skin constituents) influence the adsorption behaviour. Notably, the acetylated elastin-like peptide exhibits minimal adsorption, but the same peptide with a palm

SUBMITTER: Murthy NS 

PROVIDER: S-EPMC12319464 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature