Preventive Effect of Upland Pigmented Potatoes Against LPS-Induced Inflammation in THP-1 Macrophages.

ABSTRACT: Aim of this study was to compare the in vitro anti-inflammatory activity of three commercial potato varieties cultivated upland, Kennebec, Desirée, and Bleuet, whose extracts,   based on chemical analyses, were considered chlorogenic acid (CGA)-, carotenoid-, and anthocyanin-rich, respectively. To this aim, THP-1-derived macrophages were pretreated with extracts and then challenged with LPS. While at supraphysiological doses (50 µM), all three extracts significantly counteracted LPS-induced TNF-α, IL-1β, and IL-6, at more physiologically relevant doses (1-5 µM), only Desirée and Bleuet showed anti-inflammatory activity. We hypothesized that the high CGA content in Bleuet extract might interfere with anthocyanins. Supporting this, adding CGA to pure pelargonidin 3-glucoside and peonidin 3-g

SUBMITTER: Toccaceli M 

PROVIDER: S-EPMC12319466 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature