Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage.

ABSTRACT:

Objective

The study investigated effects of peony callus extracts (PCE) on the protective efficacy against Ultraviolet B (UVB)-induced photoageing, using in vitro and in vivo studies. The research focused on PCE's ability to protect against inflammatory factors, DNA damage and accumulation of senescent cells, along with the evaluation of the extract's potential anti-photoageing benefits to skin.

Methods

Human keratinocyte cell line (HaCaT cells), mast cells and fibroblasts were used to evaluate the role of PCE in anti-photoageing. The expression of genes of interleukin-1α (IL-1α), IL-6 and transient receptor potential vanilloid 1 (TRPV1) were tested in HaCaT cells. The histamine contents in mast cells were tested to evaluate the effect of PCE on soothing skin. Additionally,

SUBMITTER: Li Y 

PROVIDER: S-EPMC12319501 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature