Comparative Risk of Developing Interstitial Cystitis With Childhood Gastrointestinal, Urological, Autoimmune, or Psychiatric Disorders.

ABSTRACT:

Aims

Interstitial cystitis (IC) is a chronic urological condition associated with significant discomfort, posing diagnostic and therapeutic challenges. Although its etiology remains unclear, early-life conditions such as gastrointestinal (GI) disorders, urological anomalies (UA), psychiatric disorders (PD), and autoimmune diseases (AD) have been hypothesized as potential risk factors for developing IC in adulthood. This study aims to investigate these associations by conducting a retrospective cohort analysis utilizing data from the TriNetX US Collaborative Network, encompassing over 118 million patient records.

Methods

The study and control groups were established across four categories of childhood disorders, with IC incidence monitored over a 14-year period. Statistical m

SUBMITTER: Alipour-Vaezi M 

PROVIDER: S-EPMC12319504 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature