Proteomic Profiling Informs Mechanisms of Esophageal Adenocarcinoma Inhibition by Cranberry Proanthocyanidins.

ABSTRACT: Cranberry proanthocyanidins (CPACs) exert potent antiinflammatory and antibacterial activities in humans and anticancer effects in preclinical models, including those targeting esophageal adenocarcinoma (EAC). This study applied proteomic profiling to investigate CPACs' inhibitory effects on reflux-induced EAC in a rat model. Tandem mass spectrometry was applied to protein isolated from water-, CPAC-, and reflux-exposed esophagi with and without CPAC treatment. Differentially expressed proteins were identified, followed by enrichment analyses to assess CPACs' capacity to ameliorate reflux-induced changes in gene set hallmarks, pathways, and process networks. CPAC directly reversed 42.1% of reflux-induced protein alterations. Gene set enrichment analysis (GSEA) revealed CPAC mitigated 11 ha

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12319508 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature