Donor human milk storage and gastrointestinal morbidities in preterm infants: A case-control study.

ABSTRACT:

Background

Prolonged storage of donor human milk may alter its bioactive components, potentially affecting preterm infant outcomes. No prior studies have examined the impact of donor human milk storage duration on necrotizing enterocolitis or spontaneous intestinal perforation.

Methods

In a retrospective case-control study (February 2022 to January 2024) at a single neonatal intensive care unit, we evaluated preterm infants (<32 weeks' gestational age or birth weight <1700 g) receiving donor human milk. Cases (n = 36) had necrotizing enterocolitis (Bell stage ≥2A) or spontaneous intestinal perforation; controls (n = 226) were disease free. Donor human milk storage duration (days from expression to consumption) was calculated using lot expiration dates. Logistic regression as

SUBMITTER: Camilon TJM 

PROVIDER: S-EPMC12319511 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature