Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD).

ABSTRACT: The classical psychedelic drug (+)-lysergic acid diethylamide (LSD) continues to attract considerable multidisciplinary interest, and over the last eight decades, many derivatives and analogs of LSD have been synthesized. One site on the ergoline scaffold of LSD that has been frequently modified is the N¹-position, with the N¹-acylated LSD derivative 1-acetyl-LSD (1A-LSD, ALD-52) being one of the earliest examples. In more recent years, several other alkylcarbonyl- and cycloalkylcarbonyl-substituted LSD derivatives have been evaluated, including several distributed as research chemicals. Although N¹-substitution is detrimental for the activity of LSD at the 5-HT_2A receptor (the primary site of action of psychedelic drugs), N¹-acylated

SUBMITTER: Brandt SD 

PROVIDER: S-EPMC12319525 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature