Initial change in fractional excretion of total protein after SGLT2 inhibitors predicts renal prognosis in patients with chronic kidney disease.

ABSTRACT:

Background

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) reduce glomerular hyperfiltration, resulting in an initial estimated glomerular filtration rate (eGFR) dip in chronic kidney disease (CKD). The association between the initial eGFR dip after SGLT2i and proteinuria reduction has not been explored. Fractional excretion of total protein (FETP) is an index of protein leakage corrected for GFR and may be useful in addressing this issue.

Methods

FETP was calculated as (serum creatinine × urine protein)/(serum protein × urine creatinine) (in %) and the initial FETP dip was defined as 3 months/baseline FETP. The patients were divided into three groups according to the initial FETP dip tertile: FETP acute dipper, moderate dipper and riser. The association between initial

SUBMITTER: Kuno H 

PROVIDER: S-EPMC12319533 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature