Metastatic esophageal squamous cell carcinoma with paraneoplastic Raynaud phenomenon: a case report.

ABSTRACT:

Background

Incident development of Raynaud phenomenon (RP) in older adults raises concern for secondary etiologies. Malignancy is an important, yet underrecognized, cause of RP. In particular, paraneoplastic acral vascular syndrome (PAVS) describes a spectrum of secondary vascular disorders including RP and has been described in a variety of malignancies. However, presentations with squamous cell histology are uncommon, particularly in the esophagus.

Case description

A 61-year-old Caucasian male with a history of alcohol use disorder, hypertension, and hyperlipidemia presented with 3 months of progressive dysphagia and digital ischemia. RP had developed concomitantly with dysphagia and progressed to digital ischemia prior to admission. Evaluation for rheumatologic causes of

SUBMITTER: Jones AR 

PROVIDER: S-EPMC12319600 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature