Clinical features and pathological analysis of primary rib Langerhans cell histiocytosis: case series and literature review.

ABSTRACT:

Background

Langerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm characterized by the abnormal proliferation of Langerhans cells, which can infiltrate various tissues throughout the body, leading to a spectrum of organ damage. This study aims to explore the clinical characteristics, imaging manifestations, and pathological features of the disease to enhance clinical diagnosis and understanding of such conditions.

Case description

This study reviews the clinical data of four patients diagnosed with LCH at The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine. All patients met the diagnostic criteria outlined in the LCH guidelines by the American Society of Hematology, with Langerhans cells expressing CD1a, S-100, and Langerin (CD207).<

SUBMITTER: Ni G 

PROVIDER: S-EPMC12319616 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature