Case report of long-term disease control of recurrent intraoral basal cell carcinoma with vismodegib at two-year follow-up.

ABSTRACT:

Background

Intraoral basal cell carcinoma (IOBCC) is an extremely rare cancer and is usually treated with surgical excision. However, the management of recurrent IOBCC not amenable to resection is unknown. We report a case of effective treatment of recurrent IOBCC with vismodegib with rapid and durable response following only 6 months of treatment.

Case description

A 60-year-old female with IOBCC was first diagnosed in August 2016 involving right buccal mucosa and right anterior hard palate. She subsequently underwent wide local excision with involved margins. Her first local recurrence occurred four and a half years after initial diagnosis and went on to have further surgical resection. Her second local recurrence occurred 2 years later, where further surgery and radiothera

SUBMITTER: Lee HH 

PROVIDER: S-EPMC12319617 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature