Neurodevelopmental Vulnerability in Alzheimer's Disease and Frontotemporal Dementia.

ABSTRACT:

Background

Neurodevelopmental disorders (NDDs) may influence the course of Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, prior studies have focused on specific pairs of NDDs and variants of AD/FTD. Adopting a dimensional approach to NDDs and considering the heterogeneity of AD/FTD, we investigated the association between a neurodevelopmental vulnerability (DV) and the clinical presentation and age at onset of AD/FTD.

Methods

We prospectively and consecutively recruited 84 AD/FTD participants and 41 matched controls. AD/FTD participants were classified into typical (amnestic AD, behavioral FTD) and atypical (primary progressive aphasia, frontal and posterior variants of AD, right temporal variant of FTD, amnestic FTD) presentations. Participants underwe

SUBMITTER: Siguier PLM 

PROVIDER: S-EPMC12319707 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature