Brain morphology normative modelling platform for abnormality and centile estimation: Brain MoNoCle.

ABSTRACT: Normative models of brain structure estimate the effects of covariates such as age and sex using large samples of healthy controls. These models can then be applied to, for example, smaller clinical cohorts to distinguish disease effects from other covariates. However, these advanced statistical modelling approaches can be difficult to access, and processing large healthy cohorts is computationally demanding. Thus, accessible platforms with pre-trained normative models are needed. We present such a platform for brain morphology analysis as an open-source web applicationhttps://cnnplab.shinyapps.io/BrainMoNoCle/, with six key features: (i) user-friendly web interface, (ii) individual and group outputs, (iii) multi-site analysis, (iv) regional and whole-brain analysis, (v) integration with e

SUBMITTER: Little B 

PROVIDER: S-EPMC12319752 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature