Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks.

ABSTRACT: Recent advancements in MRI hardware, including ultra-high magnetic field scanners (≥7T) and MR data acquisition methods, have enhanced functional imaging techniques, allowing for the detailed study of brain function, particularly at the mesoscopic level of cortical organization. This has enabled the measurement of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal changes across cortical depth in the human brain, facilitating the study of neuronal activity at laminar level. In order to better understand the generation of cortical depth-dependent BOLD signals, biophysical modeling and computational simulations permit the characterization of the impact of vascular architecture, as well as the biophysical and hemodynamic effects at the mesoscopic leve

SUBMITTER: Baez-Yanez MG 

PROVIDER: S-EPMC12319794 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature