The effect of prolonged elbow pain and rTMS on TMS-evoked potentials: A TMS-EEG study.

ABSTRACT: Recent studies using combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) have shown that pain leads to an increase in the N45 peak of the TMS-evoked potential (TEP), potentially linked to changes in GABAergic activity. Conversely, 10 Hz repetitive TMS (10 Hz-rTMS), which provides pain relief, reduces the N45 peak. However, these studies used brief pain stimuli (lasting minutes), limiting their clinical relevance. The present study determined the effect of pain and 10 Hz-rTMS on the N45 peak in a prolonged pain model (lasting several days) induced by nerve growth factor (NGF) injection to the elbow muscle. In Experiment 1, TEPs were measured in 22 healthy participants on Day 0 (pre-NGF), Day 2 (peak pain), and Day 7 (pain recovery). In Experiment 2, we examined

SUBMITTER: Chowdhury NS 

PROVIDER: S-EPMC12319853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature