Reliability of structural brain change in cognitively healthy adult samples.

ABSTRACT: In neuroimaging research, tracking individuals over time is key to understanding the interplay between brain changes and genetic, environmental, or cognitive factors across the lifespan. Yet, the extent to which we can estimate the individual trajectories of brain change over time with precision remains uncertain. In this study, we estimated the reliability of structural brain change in cognitively healthy adults from multiple samples and assessed the influence of follow-up time and number of observations. Estimates of cross-sectional measurement error and brain change variance were obtained using the longitudinal FreeSurfer processing stream. Our findings showed, on average, modest longitudinal reliability with 2 years of follow-up. Increasing the follow-up time was associated with a subs

SUBMITTER: Vidal-Pineiro D 

PROVIDER: S-EPMC12319936 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature