Understanding the Role of Neuropsychiatric Symptoms in Functional Decline in Alzheimer's Disease.

ABSTRACT:

Objective

The authors explored classes of neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD), examined the relationship between NPS classes on rate of functional decline over time, and determined whether effects of individual symptoms on functional decline remained after controlling for NPS classes.

Methods

The authors longitudinally analyzed 9,797 study participants with mild cognitive impairment or AD at baseline in the National Alzheimer's Coordinating Center Uniform Data Set. Function was measured with the Functional Assessment Questionnaire, and NPSs were assessed by using clinician judgment. Latent class analysis (LCA) was used to identify clusters of individuals who shared similar NPS profiles. Linear mixed models were used to estimate the relationship betwe

SUBMITTER: Zhu CW 

PROVIDER: S-EPMC12320021 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature