Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling.

ABSTRACT:

Background

To investigate the overall and type-specific prevalence of high-risk human papillomavirus (HR-HPV) infection in China across different age groups and regions and to evaluate the triage of HPV-positive cases.

Methods

A prospective cross-sectional study recruited a total of 20 103 women aged 30-59 years from 13 provinces in China. Self-collected vaginal samples were tested for 14 HR-HPV types using next-generation sequencing or multiplex real-time PCR assays.

Results

The five most common types were HPV52, 58, 16, 39 and 51. The prevalence of single-type HR-HPV was 10.70%. The overall proportion of HPV16/18 was 20.67%, with a significant difference observed among provinces (p<0.05). The age-specific prevalence curve of HR-HPV followed a U-shaped pattern from 3

SUBMITTER: Li J 

PROVIDER: S-EPMC12320036 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature