Multimorbidity progression and the heterogeneous impact of healthy ageing risk factors: a multicohort study.

ABSTRACT:

Introduction

We aimed to quantify how diseases accumulate and diminish among ageing populations, and examine how modifiable risk factors influence these progressions.

Methods

In this multicohort study with four cohorts, China Health and Retirement Longitudinal Study, the English Longitudinal Study of Ageing (ELSA), the Health and Retirement Study, and the Survey of Health, Ageing and Retirement in Europe (SHARE), and 75 874 participants, we employed a multistage model that accommodated bidirectional transitions between four health stages (0, 1, 2, ≥3 conditions) from baseline to 8 years, and conducted matching analyses to examine the influence of age, sex, socioeconomic status (SES) and lifestyle factors on these transitions.

Results

Disease accumulated faster than di

SUBMITTER: Han S 

PROVIDER: S-EPMC12320038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature