Spatiotemporal epidemiology and clinical manifestations of two decades of scrub typhus in India: a systematic review and meta-analysis.

ABSTRACT:

Background

Scrub typhus, once known as tsutsugamushi fever and attributed to Rickettsia, has transformed into a growing public health concern. Despite its increasing incidence in India, comprehensive spatiotemporal analyses of scrub typhus have been lacking.

Methods

This study examines the prevalence of scrub typhus cases reported from 2003 to 2023, using available literature to provide a breakdown of cases by year and state in India, aiming to elucidate the disease's spatiotemporal dynamics. The aetiological association of Orientia tsutsugamushi and scrub typhus is based on geographical, immunological and molecular genetic studies.

Findings

This analysis identified 47 650 cumulative cases of scrub typhus in India over the past two decades. The case fatality ra

SUBMITTER: Chaturvedi R 

PROVIDER: S-EPMC12320085 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature