Associations Between Depressive Symptoms, Cognitive Impairment, and Work Productivity Loss in Patients With Bipolar Disorder: A 48-Week Longitudinal Analysis.

ABSTRACT:

Aim

To examine the relationships among work productivity loss and changes in depressive symptoms and cognitive impairment in patients with bipolar disorder and to investigate the relationship between bipolar disorder symptoms and work productivity loss.

Methods

This prospective, 48-week, longitudinal, web-based, cohort questionnaire study included adults with bipolar disorder in Japan who were employed or on sick leave. Questionnaire surveys including validated self-administered rating scales assessing cognitive impairment, work productivity loss, quality of life (QOL), depressive symptom severity, and sleep disturbance were completed every 12 weeks from baseline through Week 48. The primary endpoint was the correlation between change from baseline at 48 weeks in cognitive i

SUBMITTER: Takaesu Y 

PROVIDER: S-EPMC12320119 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature