The absence of standardization in antiphospholipid antibody testing may favor the use of 99th percentile cutoffs in antiphospholipid syndrome classification.

ABSTRACT:

Background

Classification criteria for antiphospholipid syndrome (APS) issued by the American College of Rheumatology/European Alliance of Associations for Rhuematology necessitate a positivity for any of the 3 molecular targets: lupus anticoagulant, anticardiolipin (aCL) immunoglobulin G, or anti-β2 glycoprotein I (aβ2GPI) immunoglobulin G, with the latter 2 requiring concentrations > 40 units. This specification implies having standardized and comparable calibration strategies to achieve proper patient classification. In the past, calibrator tests suffered from poor standardization; thus, the 99th percentile was established as the cutoff point.

Objectives

We aimed to find a balance between sensitivity and specificity in the laboratory criteria for patient enrollment in APS

SUBMITTER: Anunciacion-Llunell A 

PROVIDER: S-EPMC12320162 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature