Anti-influenza activity of Blumea Balsamifera (L.) DC. Extract: In vitro and in vivo evaluation against multiple influenza virus strains.

ABSTRACT: Influenza virus epidemics occur annually, posing significant public health challenges. Although anti-influenza drugs are available, newly emerged viral strains frequently develop resistance, necessitating the discovery of new antiviral reagents. This study aims to evaluate the anti-influenza virus activity of Blumea Balsamifera (L.) DC. Extract (BBE) in both in vitro and in vivo settings. The antiviral activity of BBE was assessed using the CellTiter-Glo assay and the cytopathic effect (CPE) assay in Madin-Darby canine kidney (MDCK) cells, targeting influenza virus strains H1N1, H3N2, and four influenza B viruses. Specifically, BBE demonstrated significant inhibition of MDCK cell lesions caused by the A subtypes A/WSN/33 (H1N1) and A/Hong Kong/4801/2014 (H3N2), as well as the B subtypes B/

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12320165 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature