Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants.

ABSTRACT: Histomorphometric differences in cell-matrix properties were analysed between ascending thoracic aortic aneurysm (ATAA), dissection (ATAAD) and non-aneurysmal patients, as well as across the circumference of the aneurysms in ATAA cases. Fresh anterior aortic wall samples were collected during surgery. A significant radius-to-intima-media thickness (IMT) ratio variation was observed among ATAA patients, indicating patient-specific adaptive responses. The radius-IMT ratio was significantly lower in ATAAD patients. The quantity and quality of elastin and the quantity of collagen were particularly reduced in ATAAD compared to ATAA and non-aneurysmal aortas. Matrix degradation was accompanied by an increase in the density of vascular smooth muscle cells (VSMCs), albeit with reduced expression o

SUBMITTER: Ganizada BH 

PROVIDER: S-EPMC12320207 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature