Single-atom nanozyme-mediated dihydroartemisinin delivery for self-enhanced chemodynamic therapy and ferroptosis.

ABSTRACT: Chemodynamic therapy (CDT), leveraging intracellular iron ions (Fe²⁺) and hydrogen peroxide (H₂O₂), is a highly selective therapeutic strategy with significant potential. However, its clinical application is currently hindered by the limited catalytic activity of transition metal ions and insufficient H₂O₂ supply. In this study, we present a novel and effective CDT approach using an Fe single-atom nanozyme (Fe-SAE) to deliver dihydroartemisinin (DHA), a first-line antimalarial drug. DHA serves dual roles: as a substitute for H₂O₂ and as a recruiter of Fe³⁺, significantly enhancing the reactive oxygen species (ROS) cascade for self-amplified chemodynamic and ferroptosis therapy. Upon internalization by t

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12320232 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature