Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure.

ABSTRACT:

Background

Heart failure (HF) is increasingly recognized as a multisystem syndrome involving systemic inflammation and metabolic dysfunction in addition to cardiac and hepatic impairment. Traditional liver fibrosis scores, such as the fibrosis-4 (FIB-4) index, focus solely on hepatic injury and may underestimate the broader systemic burden. The ferritin index, which adjusts serum ferritin for age and sex, may better reflect inflammatory and metabolic dysregulation, including features of metabolic hyperferritinaemia. This study aimed to evaluate the prognostic value of the ferritin index versus the FIB-4 score in predicting major adverse cardiovascular events (MACE) in patients with HF.

Materials and methods

This retrospective cohort study included 751 HF patients from the Ch

SUBMITTER: Huang CH 

PROVIDER: S-EPMC12320259 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature