Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages.

ABSTRACT: Breast cancer (BC) ranks first in morbidity and second in mortality in all female cancers, and previous studies support the contribution of tumor-associated macrophages (TAMs) to cancer progression. B7-H3 is aberrantly expressed in a variety of solid cancers, and may also promote cancer progression, but its function is still yet to be known. In this study, the importance of B7-H3 in BC pathogenesis was investigated through TAM. The expression of B7-H3 and CCR5 on macrophages/monocytes was first detected in 135 human BC tissues and peripheral blood by flow cytometry. In the tumor microenvironment, the expression of B7-H3 on TAM was positively correlated with CCR5 levels on TAM. Clinical analysis indicated that CCR5^high TAM was significantly correlated with the size of tumors (T)

SUBMITTER: Dai T 

PROVIDER: S-EPMC12320281 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature