A cost-benefit analysis of using wastewater monitoring to guide typhoid vaccine campaigns.

ABSTRACT:

Introduction

Enteric diseases are a leading cause of mortality in developing countries, yet are highly preventable. Typhoid vaccines remain underutilized, and diagnostic capacity constraints impede treatment and prevention. Wastewater monitoring could provide a more accurate picture of disease burden if detection and quantification of Salmonella Typhi in wastewater are advanced. To motivate why countries should invest to improve wastewater testing methods, we conducted a cost-benefit analysis, quantifying the value this approach could yield.

Methods

We estimated benefits that could accrue if wastewater data informed the early launch of a theoretical typhoid vaccine campaign in Cox's Bazar, Bangladesh. After empirically estimating the lead-time advantage of wastewater data ov

SUBMITTER: Keshaviah A 

PROVIDER: S-EPMC12320292 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature