An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection.

ABSTRACT: Candida albicans, responsible for approximately 70% of all Candida infections, is a leading cause of invasive candidiasis and poses a significant global health threat. With the emergence of drug-resistant strains, mortality rates have reached a staggering 63.6% in severe cases, complicating treatment options and demanding the discovery of novel therapeutic targets. To address this pressing need, using a unique multidisciplinary approach, we attempted to identify some the critical metabolic pathways that can be targeted to modulate the virulence of CAL. Condition-specific genome-scale metabolic models (GSMMs), along with a novel integrated host-CAL model developed in this study, highlighted the central role of arginine (Arg) metabolism and uncovered ALT1, an arginine biosynthesis enzyme, as

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC12320345 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature