Non-invasive light flickering reinstates visual plasticity in adult mice via lipocalin 2.

ABSTRACT:

Background

Light flickering, a non-invasive stimulation technique over recent years, has shown a promising therapeutic potential for brain dysfunctions. However, the mechanisms by which this visual stimulus exerts its beneficial effects are largely unknown.

Results

Here, we found that 7 days of 1 h 20 and 40 Hz light flickering promoted visual plasticity in primary visual cortex of adult mice. RNA sequencing results showed an increase in lipocalin 2 (LCN2) expression in the visual cortex following 20 or 40 Hz light flickering. By contrast, 80 Hz light flickering or constant light had no significant effect on either plasticity or LCN2 expression. LCN2 knock-down blocked light flickering-induced plasticity, while its overexpression mimicked the effects of light flickering. Mor

SUBMITTER: Ma C 

PROVIDER: S-EPMC12320347 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature