Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1.

ABSTRACT:

Background

The metastatic microenvironment is often rich in tumor-associated macrophages (TAMs). In uveal melanoma (UM), high levels of TAMs positively correlate with tumor progression and poorer prognosis. We hypothesize that the immunomodulation of TAMs can remodel the UM tumor microenvironment and make it more susceptible to therapeutic interventions.

Methods

In our work, we designed a novel computational pipeline that combines single-cell transcriptomics data, network analysis, multicriteria decision techniques, and pharmacophore-based docking simulations to select molecular targets and matching repurposable drugs for TAM immunomodulation. The method generates a ranking of drug-target interactions, the most promising of which are channeled towards experimental validation

SUBMITTER: Weich A 

PROVIDER: S-EPMC12320367 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature