Very long-chain fatty acids accumulate in breast cancer tissue and serum.

ABSTRACT:

Background

Breast cancer (BC) remains one of the most common cancers with relatively high mortality and is associated with alterations in fatty acid (FA) metabolism. While typical FAs have been extensively studied, there is increasing evidence for a potential role of very long chain fatty acids (VLCFAs) in cancer growth and progression.

Methods

This study involved 54 BC patients from whom samples of malignant tumor, normal fibroglandular tissue, and breast adipose tissue were collected. Their FA content was analyzed by gas chromatography-mass spectrometry. The expression of fatty acid elongases (ELOVLs) and FA-transporting proteins was analyzed in the tissues by RT-PCR and immunofluorescence.

Results

Higher levels of saturated and monounsaturated VLCFAs were found in

SUBMITTER: Pakiet A 

PROVIDER: S-EPMC12320370 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature