A multicellular vessel-on-a-chip model reveals context-dependent roles for platelets in inflammation and inflammatory hemostasis.

ABSTRACT: The immune system identifies and destroys invading pathogens. However, chronic inflammation and excessive tissue damage can occur if inflammation is not resolved or if the immune system misidentifies a threat. Therefore, the immune system must be tightly controlled. However, the complex cell-cell and cell-microenvironment interactions that regulate immune-cell recruitment are challenging to recapitulate in 2-dimensional in vitro models, and poorly representative of human physiology in in vivo animal models. Organ-on-a-chip technology has the potential to overcome these limitations and provide powerful preclinical models. In this study, we developed a vessel-on-a-chip model to investigate the role of platelets in inflammation and inflammatory hemostasis. Endothelial vessels cultured in the

SUBMITTER: Riddle RB 

PROVIDER: S-EPMC12320429 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature