Rising total leukocyte counts correspond with rising platelet counts in thrombotic thrombocytopenic purpura.

ABSTRACT: Thrombotic thrombocytopenic purpura (TTP) is a rare disorder involving pathological platelet-von Willebrand factor interaction, resulting in microvascular thrombosis. The consumption of platelets in TTP microthrombi results in severe thrombocytopenia which resolves with resolution of the microvascular thrombosis. Over the course of treatment, patient platelet counts often rise and fall multiple times before stable remission is achieved. On casual inspection, we noted that total leukocyte counts follow a pattern that appears to correspond to platelet counts. To explore whether changing leukocyte counts track significantly with changing platelet counts, we examined paired daily platelet counts and total leukocyte counts in 27 episodes of TTP in 13 patients across 2 institutions comprising 42

SUBMITTER: Samia NI 

PROVIDER: S-EPMC12320433 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature