Photodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study.

ABSTRACT:

Introduction

Fungal keratitis is a leading cause of corneal blindness, with current antifungal treatments having limited efficacy. One promising treatment modality is Rose Bengal (RB) photodynamic antimicrobial therapy (PDAT) that has shown mixed success against fungal keratitis. Therefore, there is a need to explore the antimicrobial efficacy of other green-light activated photosensitizers that have deep penetration in the cornea to combat the deep fungal infections, such as Erythrosin B (EB) and Eosin Y (EY).

Objective

This study will explore PDAT inhibitory effects with different photosensitizers, RB, EB, and EY against two common fungal ocular isolates, Aspergillus spp. and Fusarium spp.

Methods

Twelve fungal isolates (Fusarium spp., n = 6, Aspergillus spp., n = 6

SUBMITTER: Chou B 

PROVIDER: S-EPMC12320518 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature