The Effect of HCV on Methadone Dose During Pregnancy.

ABSTRACT: Pregnancy is a time of high patient motivation to initiate treatment for opioid use disorder (OUD). Hepatic drug metabolism can be altered by pregnancy and hepatitis C virus (HCV) infection. We aimed to examine the impact of HCV during pregnancy on methadone dosing. Retrospective chart review of all pregnant patients with OUD admitted for initiation of methadone from 1/2020-6/2022. Associations were examined using Student's T-tests, chi-squared tests, Fisher's exact tests and univariate and multivariate linear regression. We identified 191 pregnancies initiated on methadone, of which 188 were screened for HCV. 111 (59.0%) were HCV Antibody (Ab)+, of whom 108 were tested for HCV RNA and 66 (61.1%) were HCV RNA+. The median viral load was 498,500 IU/mL (range 19-46,000,000 IU/mL). Fibrosis-4

SUBMITTER: Boudova S 

PROVIDER: S-EPMC12320570 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature