Incidence and reasons for discontinuation of anti-VEGF treatment in neovascular age-related macular degeneration.

ABSTRACT:

Purpose

To explore the factors and frequency of interruptions in intravitreal treatment for patients with neovascular age-related macular degeneration (AMD) and to evaluate the demographic and clinical factors linked to the reasons for discontinuation.

Methods

In this multicentre study, patients who began anti-vascular endothelial growth factor (VEGF) treatment between January 2019 and December 2021 for treatment-naïve neovascular exudative AMD were retrospectively analysed. The overall incidence of treatment discontinuation, along with the rates for each specific cause, was calculated. The probability of each cause of discontinuation over time from the start of treatment, as well as the risk factors associated with each case, was also determined.

Results

655 individu

SUBMITTER: Borrelli E 

PROVIDER: S-EPMC12320594 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature