Clinical presentation of bone tumours in children and young people: a systematic review and meta-analysis.

ABSTRACT:

Background

Children and young people (CYP) with bone tumours often experience lengthy intervals prior to diagnosis that can lead to increased morbidity and mortality. Early diagnosis is key to optimising treatment options and long-term outcomes. This review aims to describe symptomatology at diagnosis, in order to develop interventions to accelerate diagnosis.

Methods

A literature search of MEDLINE and EMBASE was conducted for studies published between January 2008 and May 2023, reporting signs and symptoms in CYP with bone tumours. Pooled proportions of symptoms and signs were calculated.

Results

16 studies (1452 patients; 492 osteosarcoma and 932 Ewing's sarcoma) were included in the analysis. The most prevalent symptoms were pain (64%, 95% CI 52% to 75%) and swelli

SUBMITTER: Liu JF 

PROVIDER: S-EPMC12320600 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature