Efficacy and safety of direct oral anticoagulants in patients with venous thrombosis and inherited thrombophilia.

ABSTRACT: Introduction: Inherited thrombophilia screening is widely performed in patients with venous thromboembolism (VTE). Although recent studies suggest that direct oral anticoagulants (DOACs) may provide comparable efficacy and safety to Vitamin K antagonists (VKAs) in this population, robust evidence to support their extensive use is still lacking. We aimed to evaluate the rates of VTE recurrence and overall bleeding in patients with inherited thrombophilia treated with DOACs versus VKAs, with particular interest in those with severe thrombophilia. Methods: Using the electronic database of the largest healthcare provider in Israel, we conducted a retrospective search for patients with a recorded VTE between 2012 and 2021 (the index event). Patients aged 18 or older at the time of

SUBMITTER: Warwar A 

PROVIDER: S-EPMC12320646 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature