Fibrinogen is the key factor associated with tremor relief and recurrence after magnetic resonance-guided focused ultrasound thalamotomy.

ABSTRACT:

Introduction

Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is safe and effective for tremor disorders such as essential tremor (ET), but whether preoperative serum profiles mediate tremor recurrence after treatment requires further investigation.

Methods

We retrospectively analyzed the data of 59 ET patients who underwent unilateral MRgFUS thalamotomy during 2018-2020. Tremor severity was assessed off-medication using the Clinical Rating Scale for Tremor (CRST), with contralateral hand tremor measured via a derived CRST subscale. Short-term tremor relief was defined as ≥ 50 % reduction at 1-month postoperatively, and tremor recurrence was defined as a worsening by 25 % and at least 8 points within 12 months. Multivariate logistic regression analyses were

SUBMITTER: Lin J 

PROVIDER: S-EPMC12320648 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature